Table 1.

Table displays comparison of the key features across different Pik3ca genetic models used in this study.

DOI: http://dx.doi.org/10.7554/eLife.12703.023

Mutant allele	H1047R		E545K
Cre driver	hGFAP-cre(dox from E0.5)	hGFAP-cre(dox from P1)	Nestin-cre	hGFAP-cre	Nestin-creERT2(tamoxifen @P0/P1)
GoF expression onset	Late embryonic	Neonatal	Early embryonic	Late embryonic	Neonatal
Viability	Lethal by weaning age	Viable	Viable	Viable	Viable
Megalencephaly	✓	X	✓	✓ (intermediate)	X
Hydrocephalus	✓	X	X	X	X
Increased cell size	✓	Not tested	✓	X	X
Cortical dysplasia	✓	X	✓	X	X
White matter dysplasia	✓	X	✓	✓ (data not shown)	X
Epilepsy	Not tested	Not tested	✓	Not tested	✓