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The molecular composition of the APC/C. The subunits of the mammalian APC/C are indicated. APC3, APC6, APC7, and APC8 contain tetracopeptide-repeat (TPR) domains, and together with APC12 for the TPR lobe. APC1, APC4, and APC5 form the ‘platform’ domain of the APC/C. The catalytic core is composed of APC11 (Ring) and APC2 (Cullin). APC10 together with one the co-activators Cdc20/Cdh1 forms the degron-recognition domain
