Table 1.
Human APC/C subunits and co-activators
| APC/C subunits | Alternative names | Human gene name | Function |
|---|---|---|---|
| APC1 | – | ANAPC1 | Scaffold, PC repeats |
| APC2 | – | ANAPC2 | catalytic core-cullin subunit |
| APC3 | Cdc27 | CDC27 | Scaffold with TPR motifs |
| APC4 | – | ANAPC4 | ‘Platform’ subunit |
| APC5 | – | ANAPC5 | ‘Platform’ subunit |
| APC6 | Cdc16 | CDC16 | Scaffold with TPR motifs |
| APC7 | – | ANAPC7 | Scaffold with TPR motifs |
| APC8 | Cdc23 | CDC23 | Scaffold with TPR motifs |
| APC10 | Doc1 | ANAPC10 | Substrate recognition |
| APC11 | – | ANAPC11 | Catalytic core-RING H2 domain |
| APC12 | Cdc26 | CDC26 | Stabilizes APC6 |
| APC13 | – | ANAPC13 | Stabilizes APC3, APC6 and APC8 |
| APC15 | – | ANAPC15 | Mediated Cdc20/MCC turnover |
| APC16 | – | ANAPC16 | TPR subunit |
| Co-activators | Alternative names | Human gene name | Function |
|---|---|---|---|
| Cdc20 | P55-Cdc20 | CDC20 | Substrate recruitment/APC/C activation |
| Cdh1 | Fizzy-related, Hct1 homolog | FZR1 | Substrate recruitment/APC/C activation |
Proteins names, common alternative names, human gene symbols and designated functions of APC/C subunits and co-activators are listed