Fig. 9.

Release profiles for slices of caplets at pH 1 (◇, ◆), pH 5.5 (○,●), pH 6.8 (■, □) and pH 7.8 (▲, △). The caplets were loaded with (a) ranitidine, (b) paracetamol and (c) indomethacin, with a 4.4% loading (△,□,◇,○) and a 22.2% loading (▲,■,◆,●). The lines show data fits using the Peppas model, given by Eq. 2., to caplets with a 4.4% drug loading (dashed line) and a 22.2% drug loading (continuois line). In (c), release from pure indomathcin crystals shown at pH 1 (+) and pH 6.8 (−) (see insert).