Table 2.

Differentially expressed proteins in liver of HC and LC groups identified by two-dimensional gel electrophoresis analysis and MALDI-TOF-MS^a,b

Spot number	Protein name	Accession number	Molecular weight, kDa	PI	Protein expression
Oxidative stress (4)
1	Regucalcin (RNG)	gi|195972815	33,956	5.42	Down
7	Superoxide dismutase [Cu-Zn] (SOD1)	gi|27807109	15,844	5.85	Down
5	Glutathione S-transferase A1 (GSTA1)	gi|118151372	25,549	8.66	Down
17	Protein disulfide-isomerase A3 precursor (PDIA3)	gi|148230374	57,293	6.38	Down
Mitochondrial function (6)
3	Glutamate dehydrogenase 1 (GLUD1)	gi|347300243	61,668	8.03	Up
6	ATP synthase subunit beta (ATPSβ)	gi|28461221	56,249	5.15	Down
8	Aldehyde dehydrogenase (ALDH)	gi|115496214	57,073	7.55	Up
10	Cytochrom c oxidase subunit Via (COX6A1)	gi|162817	9, 501	6.13	Down
13	60 kDa heat shock protein (HSP60)	gi|262205483	61,110	5.71	Down
18	4-hydroxy-2-oxoglutarate aldolase (HOGA1)	gi|73998495	38,052	7.6	Up
Metabolism (5)
11	Agmatinase (AGMAT)	gi|194674166	39,419	8.77	Up
12	Acetyl-Coenzyme A acetyltransferase 2 (ACAT2)	gi|109659291	41,657	6.46	Up
14	3-hydroxyanthranilate 3,4-dioxygenase (HAAO)	gi|115495835	32,701	5.51	Down
16	Alpha enolase (ENO1)	gi|4927286	47,589	6.44	Up
4	UMP-CMP kinase-like isoform 1	gi|109087275	26,237	8.14	Up
RA metabolism (2)
9	Retinal dehydrogenase 1 (RALDH1)	gi|57526379	55,417	6.37	Up
20	Retinol-binding protein (RBP)	gi|415585	15,473	5.89	Down
Transport protein (2)
2	Hemoglobin subunit beta-A	gi|122540	16,068	6.75	Down
15	Albumin precursor	gi|1930850052	68,266	5.58	Down
Cytoskeletal structure (1)
19	Actin,beta	gi|148744172	42,022	5.29	Down

^aMALDI-TOF-MS = matrix-assisted laser desorption ionization-time of flight mass spectrometry. pI isoelectric point; gi GenInfo Identifier

^bProtein name and accession numbers were derived from NCBI database