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. 2016 Feb 6;15:26. doi: 10.1186/s12933-016-0340-6

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© Hellberg et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — ¹⁸F-FMCH uptake and the density of macrophages in atherosclerotic plaques in diabetic IGF-II/LDLR^−/−ApoB^100/100 mice. a Macrophage immunostaining (Mac-3, brown) of aortic plaque. The dotted line separates areas of visually high and low macrophage density. Scale bar 100 µm. b Binary image from ImageJ software shows Mac-3-positive staining as black, and the areal percentage of positive staining is measured. c Autoradiograph of the plaque shows high radioactivity co-localizing with the Mac-3-positive staining. d Quantitative uptake of ¹⁸F-FMCH in plaque areas with low, intermediate or high areal percentage of Mac-3-positive staining