Table 2.

Quantitative results of histology in non-diabetic (LDLR^−/−ApoB^100/100) and diabetic (IGF-II/LDLR^−/−ApoB^100/100) atherosclerotic mice

	LDLR−/−ApoB100/100 (n = 8)	IGF-II/LDLR−/−ApoB100/100 (n = 9)
Intima-to-media ratio (plaque size)	2.7 ± 0.88	1.8 ± 0.51
Mac-3 positive area (%)	15 ± 2.3	17 ± 0.98
iNOS positive area (%)	14 ± 1.3	14 ± 1.7
MRC-1 positive area (%)	30 ± 1.3	32 ± 1.2
CD36 positive area (%)	24 ± 1.6	28 ± 0.66

In addition to plaque size (intima-to-media ratio), areal percentages of macrophages (Mac-3), M1 polarized macrophages (iNOS), M2 polarized macrophages (MRC-1) and scavenger receptor (CD36) in atherosclerotic lesions in the aortic root are shown. The data are expressed as mean ± SEM. No statistically significant differences were observed between the mouse strains