Table 4.
Aortic uptake of 18F-FMCH and 18F-FDG in ex vivo autoradiography
| 18F-FMCH | 18F-FDG | ||||
|---|---|---|---|---|---|
| LDLR−/−ApoB100/100 | IGF-II/LDLR−/−ApoB100/100 | C57BL/6N | LDLR−/−ApoB100/100 | IGF-II/LDLR−/−ApoB100/100 | |
| Adventitia | 140 ± 9.1 | 160 ± 12 | 100 ± 8.4a | 210 ± 39 | 130 ± 12 |
| Wall | 76 ± 5.8 | 89 ± 6.8 | 69 ± 7.5 | 160 ± 18 | 140 ± 12 |
| Plaque | 190 ± 11 | 240 ± 20a | NA | 320 ± 30 | 290 ± 20 |
| Plaque-to-wall ratio | 2.5 ± 0.10 | 2.6 ± 0.085 | NA | 2.1 ±0.16 | 2.1 ± 0.16 |
| Plaque vs. wall p value | <0.001 | <0.001 | NA | 0.0023 | <0.001 |
| Plaque vs. adventitia p value | 0.018 | 0.022 | NA | 0.061 | <0.001 |
Uptake of the tracers in different parts of vascular tissue are measured in non-diabetic (LDLR−/−ApoB100/100) and diabetic (IGF-II/LDLR−/−ApoB100/100) atherosclerotic mice and in healthy (C57BL/6N) controls. The results are expressed as count densities (photo-stimulated luminescence per mm2, mean ± SEM).
NA not applicable
aa significant difference as compared with LDLR−/−ApoB100/100 mice