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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: Virology. 2015 Dec 1;488:179–186. doi: 10.1016/j.virol.2015.11.014

Figure 6. pUL56 promotes infection of the superior cervical ganglion.

Figure 6

Parental, ΔUL56, ΔUS9, or a ΔUL56/ΔUS9 double-mutant virus was injected into the anterior chamber of the eye of male Long Evans rats. The location of the injection in the eye is indicated by an asterisk (*). Animals were sacrificed at the indicated times and the superior cervical ganglion (SCG) was removed, sectioned, and scored for infected neurons based on red-fluorescence emissions from the pUL25/mCherry capsid fusion. The symbol ‘†’ denotes the time of imminent death from infection. The lower dashed line indicates the number of neurons in the SCG that project directly to the eye. The upper dashed line indicates the total number of neurons, ≅ 30,000, that comprise the SCG.