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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Cancer Discov. 2015 Oct 26;6(2):133–146. doi: 10.1158/2159-8290.CD-15-0583

Figure 4. CAR T-cell design. (A) Structure of the CAR.

Figure 4

The CAR typically contains a single chain fragment variable (scFv) binding domain specific for mesothelin fused to a transmembrane domain and intracellular signaling domain (CD3ζ and CD28 or 4-1BB). The CAR expressed into patient’s own T cells after transduction provides both specificity and effector function activation (B) Different generations of the MSLN CAR. Three generations of CAR T cells differing by their signaling domains have been designed to increase the activation strength of T cells.