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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Neurobiol Learn Mem. 2016 Jan 13;128:110–116. doi: 10.1016/j.nlm.2016.01.003

Figure 3.

Figure 3

Nicotine withdrawal and frontostriatal BDNF. Data are Mean ± SEM. All BDNF values were expressed as percent change with respect to the control (sal-sal) group. Bar charts depicting changes in the BDNF levels in the striatum and PFC (A) and the striatal/prefrontal ratios (B), across all treatment groups. Striatal BDNF levels were higher in the mecamylamine precipitated nicotine withdrawal group (nic-mec) as compared to the nicotine control group (nic-sal). Prefrontal BDNF levels declined in nic-mec mice. Moreover, the ratio of striatal to prefrontal BDNF levels robustly increased in nic-mec animals. (C) Scatter plots show no association between the strategy switching performance and either the striatal or prefrontal BDNF levels. (D) Striatal/prefrontal BDNF ratios exhibited a significant positive correlation with trial to attain strategy switching criterion. Higher ratios illustrate poor performance. *, p < 0.05 vs. sal-sal; #, p <0.05 vs. nic-sal