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. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: J Immunol. 2016 Jan 15;196(4):1443–1448. doi: 10.4049/jimmunol.1501634

Figure 4. Anti-CD99 ameliorates relapse in ongoing RR-EAE and reduces CNS inflammatory infiltrates.

Figure 4

(A) Animals with ongoing RR-EAE were treated with anti-CD99 (open circles) or control IgG (closed circles) during the secondary phase of disease at the onset of relapse. **p< 0.001 by Mann-Whitney U test. (B–C) CNS tissues were harvested at the end of the experiment to enumerate inflammatory APC (B) and T-cell (C) infiltrates in the CNS of RR-EAE mice as described in Fig 3. Data in A are representative of 3 independent experiments (n= 8 mice/group for each experiment; **p< 0.001 by Mann-Whitney U test). Data in B–C are pooled from 12-mice/treatment group. Error bars indicate SEM. **p< 0.05 compared to control IgG by two way ANOVA (B,C).