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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Am J Obstet Gynecol. 2015 Sep 30;214(2):192–202. doi: 10.1016/j.ajog.2015.09.082

Figure 3. Overproduction of NO mediates maternal diabetes-induced yolk sac vasculopathy.

Figure 3

Maternal diabetes-induced oxidative stress activates ASK1. The phosphorylation of ASK1 stimulates iNOS gene expression, which generates very high concentrations of NO. The detrimental role of NO derived from iNOS includes DNA damage, ER stress, NF-kB inhibition, and respiratory inhibition, all of which contribute to yolk sac vasculopathy.