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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: J Neurosci Res. 2016 Jan 17;94(4):329–338. doi: 10.1002/jnr.23713

Figure 5. Effects of eticlopride on phosphorylation of SFKs and expression of SKFs and mGluR5 in the PSD of rat striatal neurons.

Figure 5

(A) Expression of PSD-95 and Rab3A in homogenate (H), crude synaptosome (P2), and PSD fractions from rat striatal neurons. (B) Effects of eticlopride on Fyn and Src expression and Y416 phosphorylation in the PSD. (C) Effects of eticlopride on mGluR5 expression in the PSD. Note that eticlopride enhanced Fyn and mGluR5 expression and Y416 phosphorylation in PSD fractions. Representative immunoblots are shown left to the quantified data (B and C). Rats were given an injection of saline (Sal) or eticlopride (Eti, 0.5 mg/kg, i.p.) and were sacrificed 1 h after drug injection for biochemical fractionation of PSD proteins (B and C). Data are presented as means ± SEM and were analyzed by Student’s t-test (n = 5 per group). *P < 0.05 versus saline.