Table 3.
Multivariate logistic regression for top 8 health issues of gynecologic cancer survivors
| Fatigue | Sexual | Neurologic | Urinary | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variablea | OR | 95%CI | p | OR | 95%CI | p | OR | 95%CI | p | OR | 95%CI | p |
| Age (≤ 40 yrs) | .00 | |||||||||||
| 41–50 yrs | 0.95 | 0.57, 1.58 | .83 | |||||||||
| 51–60 yrs | 0.62 | 0.38, 1.00 | .05 | |||||||||
| 61–70 yrs | 0.30 | 0.18, .51 | .00 | |||||||||
| 71+ yrs | 0.09 | 0.04, 0.17 | .00 | |||||||||
| BMI (ref=under/normal weight <25) | .09 | |||||||||||
| Overweight 25.0 – 29.9 | 1.30 | .92, 1.83 | .14 | |||||||||
| Obese 30.0 + | 1.44 | 1.03, 2.0 | .03 | |||||||||
| Current smoker (ref=no) | 1.54 | 1.01, 2.35 | .04 | 1.98 | 1.26, 310 | .00 | 2.02 | 1.30, 3.13 | .00 | 1.55 | 1.02, 2.37 | .04 |
| Race (ref=White) | ||||||||||||
| Black | ||||||||||||
| Hispanic | ||||||||||||
| Other | ||||||||||||
| Marital (ref=Married/partner) | ||||||||||||
| Not married/no partner | 0.44 | .32, .61 | .00 | 1.38 | 1.03, 1.85 | .03 | ||||||
| Cancer dx (ref=Endometrial) | ||||||||||||
| Cervical | ||||||||||||
| Ovarian | ||||||||||||
| Vaginal | ||||||||||||
| Vulvar | ||||||||||||
| Other | ||||||||||||
| Time since dx (ref=<3 yrs) | .05 | .01 | .00 | |||||||||
| 3–5 yrs | 0.99 | .67, 1.46 | .96 | 1.28 | 0.84, 1.94 | .25 | 1.65 | 1.08, 2.53 | .02 | |||
| 5–10 yrs | 1.25 | .89, 1.76 | .20 | 1.72 | 1.19, 2.50 | .00 | 2.65 | 1.83, 3.85 | .00 | |||
| 10+ yrs | 1.71 | 1.12, 2.61 | .01 | 2.07 | 1.30, 3.31 | .00 | 2.86 | 1.83, 4.45 | .00 | |||
| Point in disease spectrum (ref=NED) | .00 | .01 | ||||||||||
| Recurrent disease | 2.25 | 1.47, 3.42 | .00 | 1.83 | 1.21, 2.75 | .00 | ||||||
| Primary treatment | 4.12 | 0.72, 23.6 | .11 | 2.01 | .43, 9.35 | .37 | ||||||
| Treatment modality (ref=Surgery) | .00 | .00 | .00 | .00 | ||||||||
| Surgery, chemotherapy | 3.45 | 2.34, 5.08 | .00 | 1.57 | 1.04, 2.36 | .03 | 4.04 | 2.68, 6.10 | .00 | 0.68 | 0.45,1.04 | .08 |
| Surgery, radiation | 1.83 | 1.19, 2.80 | .01 | 2.29 | 1.43, 3.67 | .00 | 1.80 | 1.12, 2.89 | .01 | 1.85 | 1.21,2.83 | .00 |
| Chemotherapy, radiation | 3.21 | 1.92, 5.38 | .00 | 2.05 | 1.18, 3.56 | .01 | 2.72 | 1.58, 4.67 | .00 | 2.49 | 1.48, 4.18 | .00 |
| Surgery, chemo, radiation | 4.01 | 2.68, 6.00 | .00 | 3.29 | 2.16, 5.01 | .00 | 5.93 | 3.89, 9.03 | .00 | 2.03 | 1.37, 3.02 | .00 |
| Radiation only | 1.73 | 0.87, 3.44 | .12 | 3.36 | 1.49, 7.62 | .02 | 1.10 | 0.48, 2.54 | .82 | 2.10 | 1.06, 4.14 | .03 |
| Chemotherapy only | 0.57 | 0.07, 4.81 | .60 | 1.21 | 0.20, 7.17 | .83 | 1.86 | 0.35, 9.91 | .47 | 0.00 | 0.00, 0.00 | 1.0 |
| Hormonal therapy | 0.75 | 0.06, 10.1 | .83 | 0.80 | 0.07, 9.10 | .86 | 0.00 | 0.00, 0.00 | 1.0 | 0.00 | 0.00, 0.00 | 1.0 |
| Sleep | Bowel | Memory | Depression | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variablea | OR | 95%CI | p | OR | 95%CI | p | OR | 95%CI | p | OR | 95%CI | p |
| Age (ref = ≤ 40 yrs) | .00 | .00 | .00 | |||||||||
| 41–50 yrs | 1.30 | 0.77, 2.19 | .33 | 0.84 | 0.48, 1.46 | .54 | .77 | .46, 1.30 | .33 | |||
| 51–60 yrs | 0.94 | 0.57, 1.53 | .80 | 0.59 | 0.35, 1.00 | .05 | .65 | .40, 1.07 | .09 | |||
| 61–70 yrs | 0.70 | 0.42, 1.16 | .17 | 0.37 | 0.21, 0.64 | .00 | .43 | .26, .73 | .00 | |||
| 71+ yrs | 0.51 | 0.29, 0.89 | .02 | 0.27 | 0.15, 0.49 | .00 | .32 | .18, .57 | .00 | |||
| BMI (ref=under/normal weight <25) | .10 | |||||||||||
| Overweight 25.0 – 29.9 | .74 | 0.53, 1.05 | .10 | |||||||||
| Obese 30.0 + | .71 | 0.50, 1.00 | .05 | |||||||||
| Current smoker (ref=no) | 1.95 | 1.24, 3.06 | .01 | 1.77 | 1.12, 2.82 | .02 | 1.46 | 0.94, 2.26 | .09 | |||
| Race (ref=White) | .04 | .05 | ||||||||||
| Black | 1.74 | 0.96, 3.15 | .07 | 1.67 | 0.91, 3.09 | .10 | ||||||
| Hispanic | 1.67 | 1.08, 2.59 | .02 | 1.27 | 0.80, 2.02 | .31 | ||||||
| Other | 0.87 | 0.39, 1.91 | .72 | 2.41 | 1.13, 5.11 | .02 | ||||||
| Marital (ref=Married/partner) | ||||||||||||
| Not married/no partner | ||||||||||||
| Cancer dx (ref=Endometrial) | .05 | |||||||||||
| Cervical | 1.51 | 0.98, 2.33 | .06 | |||||||||
| Ovarian | 1.52 | 0.93, 2.49 | .10 | |||||||||
| Vaginal | 2.75 | 1.44, 5.29 | .00 | |||||||||
| Vulvar | 1.10 | 0.62, 1.94 | .74 | |||||||||
| Other | 1.24 | 0.20, 7.54 | .82 | |||||||||
| Time since dx (ref=<3 yrs) | .00 | .00 | .04 | |||||||||
| 3–5 yrs | 0.95 | 0.63. 1.42 | .80 | 2.41 | 1.58, 3.69 | .00 | 1.03 | .67, 1.57 | .91 | |||
| 5–10 yrs | 1.63 | 1.15, 2.31 | .01 | 2.16 | 1.46, 3.19 | .00 | 1.32 | .91, 1.93 | .14 | |||
| 10+ yrs | 2.19 | 1.41, 3.39 | .00 | 2.41 | 1.49, 3.92 | .00 | 1.87 | 1.18, 2.95 | .01 | |||
| Point in disease spectrum (ref=NED) | ||||||||||||
| Recurrent disease | ||||||||||||
| Primary treatment | ||||||||||||
| Treatment modality (ref=Surgery) | .00 | .00 | .00 | .02 | ||||||||
| Surgery, chemotherapy | 3.07 | 2.08, 4.52 | .00 | 2.50 | 1.47, 4.25 | .00 | 2.90 | 1.94, 4.33 | .00 | 1.92 | 1.27, 2.89 | .00 |
| Surgery, radiation | 1.85 | 1.18, 2.91 | .01 | 4.54 | 2.79, 7.39 | .00 | 0.97 | 0.58, 1.60 | .89 | 1.26 | 0.77, 2.07 | .35 |
| Chemotherapy, radiation | 2.65 | 1.56, 4.50 | .00 | 4.00 | 2.26, 7.08 | .00 | 2.24 | 1.24, 4.05 | .01 | 2.41 | 1.40, 4.17 | .00 |
| Surgery, chemo, radiation | 2.82 | 1.88, 4.24 | .00 | 5.08 | 3.28, 7.89 | .00 | 2.64 | 1.74, 4.03 | .00 | 1.79 | 1.17, 2.74 | .01 |
| Radiation only | 2.20 | 1.07, 4.52 | .03 | 2.75 | 1.30, 5.81 | .01 | 1.01 | 0.41, 2.47 | .99 | 1.56 | 0.70, 3.44 | .27 |
| Chemotherapy only | 0.49 | 0.05, 4.33 | .52 | 2.02 | 0.36, 11.4 | .43 | 1.18 | 0.21, 6.64 | .85 | 0.62 | 0.07, 5.33 | .66 |
| Hormonal therapy | 1.63 | 0.14, 19.1 | .70 | 0.00 | 0.00, 0.00 | 1.0 | 1.61 | 0.14, 18.4 | .70 | 0.00 | 0.00, 0.00 | 1.0 |
a
The following variables were included in all regression models: age, BMI, smoking status, race, marital status, cancer disease site, time since cancer diagnosis, point in disease spectrum, and treatment modality.