Table 3.
Genetic risk scores and incident coronary heart disease according to self-reported family history
| Self-reported family history | GRS | Intermediate riska |
High riskb |
P intxn | ||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |||
| Yes | GRS50 | 1.29 (1.07–1.56) | 0.007 | 1.75 (1.43–2.15) | 7.7 × 10−8 | 0.33 |
| No | GRS50 | 1.43 (1.21–1.68) | 1.9 × 10−5 | 1.96 (1.63–2.35) | 7.4 × 10−13 | |
| Yes | GRS27 | 1.26 (1.05–1.52) | 0.013 | 1.64 (1.34–2.01) | 2.1 × 10−6 | 0.38 |
| No | GRS27 | 1.23 (1.05–1.44) | 0.009 | 1.67 (1.39–1.99) | 2.1 × 10−8 | |
Risk estimates were adjusted for age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, and prevalent diabetes. GRS27 risk boundaries (SD): low ≤− 0.8547; intermediate >− 0.8547 and ≤0.8236; high > 0.8236. GRS50 risk boundaries (SD): low ≤− 0.8517; intermediate >− 0.8517 and ≤0.8360; high > 0.8360. Pintxn: Pinteraction between GRS as a continuous variable and self-reported family history status for the incident CHD outcome.
HR, hazard ratio; CI, confidence interval; GRS, genetic risk score; GRS27, 27-variant genetic risk score; GRS50, 50-variant genetic risk score.
aIntermediate risk: Quintiles 2, 3, and 4 compared with low risk (Quintile 1).
bHigh risk: Quintile 5 compared with low risk (Quintile 1).