Table 4.

Genetic risk scores and coronary heart disease risk in young and old

	≤Median agea				>Median agea				P intxn b
	Intermediate riskc		High riskd		Intermediate riskc		High riskd
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Model 1e
GRS50	1.55 (1.22–1.98)	0.0004	2.40 (1.84–3.12)	7.5 × 10−11	1.33 (1.15–1.53)	7.9 × 10−5	1.75 (1.49–2.06)	6.5 × 10−12	0.0029
GRS27	1.53 (1.20–1.94)	0.0005	2.24 (1.72–2.90)	1.4 × 10−9	1.18 (1.03–1.35)	0.02	1.52 (1.30–1.78)	1.8 × 10−7	0.0004
Model 2f
GRS50	1.53 (1.20–1.96)	0.0006	2.35 (1.81–3.06)	2.0 × 10−10	1.32 (1.14–1.52)	0.0002	1.71 (1.45–2.01)	6.5 × 10−11	0.0025
GRS27	1.50 (1.18–1.91)	0.0009	2.19 (1.69–2.84)	4.1 × 10−9	1.17 (1.02–1.34)	0.03	1.48 (1.27–1.73)	9.6 × 10−7	0.0003

GRS27 had a mean of 2.49 and standard deviation of 0.34; GRS50 had a mean of 3.82 and standard deviation of 0.43. Risk boundaries (27-SNPs GRS): low GRS ≤− 0.8547; intermediate GRS >− 0.8547 and ≤0.8236; high GRS > 0.8236. Risk boundaries (50-SNPs GRS): low GRS ≤− 0.8517; intermediate GRS >− 0.8517 and ≤0.8360; high GRS > 0.8360.

HR, hazard ratio; CI, confidence interval; GRS, genetic risk score; GRS27, 27-variant genetic risk score; GRS50, 50-variant genetic risk score.

^aMedian age: 57.6.

^b P _intxn: for interaction between continuous GRS and median age status for the incident CHD outcome.

^cIntermediate risk: Quintiles 2, 3, and 4 compared with low risk (Quintile 1).

^dHigh risk: Quintile 5 compared with low risk (Quintile 1).

^eModel 1: adjusted for age, sex, systolic blood pressure, use of antihypertensive medication, smoking, apoB, apoA-I, and prevalent diabetes.

^fModel 2: Model 1 and additional adjustment for family history.