Table 5.
Top 10 predicted interactions for the NR dataset using RLS-KF based on the SK-PCFP combination.
| Order | KEGG drug ID | Drug name | KEGG target ID | Target name |
|---|---|---|---|---|
| 1 | D00316 | Etretinate | hsa6096 | RAR-related orphan receptor β |
| 2 | D00182 | Norethisterone | hsa2099 | Estrogen receptor 1 |
| 3 | D00443 | Spironolactone | hsa5241 | Progesterone receptor |
| 4 | D00327 | Fluoxymesterone | hsa5241 | Progesterone receptor |
| 5 | D00075 | Testosterone | hsa5241 | Progesterone receptor |
| 6 | D00075 | Testosterone | hsa2099 | Estrogen receptor 1 |
| 7 | D01115 | Eplerenone | hsa2908 | Glucocorticoid receptor |
| 8 | D01217 | Dydrogesterone | hsa2099 | Estrogen receptor 1 |
| 9 | D00951 | Medroxyprogeste rone acetate | hsa2099 | Estrogen receptor 1 |
| 10 | D00094 | Tretinoin | hsa3174 | Hepatocyte nuclear factor 4 gamma |