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. 2015 Sep 4;103(11):3649–3658. doi: 10.1002/jbm.a.35505

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© 2015 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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mRNA expression of (A) Runx2, (B) Col 1, (C) ALP, (D) BMP2, (E) BSP, and (F) OC by qRT‐PCR, presented as x‐fold changes relative to the expression of the mean of the calibrator sample LD‐OM. A: Runx2 expression is downregulated by osteogenic medium (p = 0.005) and upregulated by high cell seeding density (p = 0.001). B: Col1 expression is upregulated by high cell seeding density (p = 0.001). C: ALP expression, disclosing a significant relationship between high cell density, osteogenic medium, and number of days (p = 0.026). D: BMP2 expression is upregulated by osteogenic medium (p < 0.001) and high cell seeding density (p = 0.003). E: BSP expression is upregulated by osteogenic medium (p < 0.001) and high cell seeding density (p = 0.033). F: OC expression is upregulated by osteogenic medium (p = 0.002) and high cell seeding density (p = 0.013). The data are presented as means ± 95% confidence intervals.