Table 3.
Pharmacokinetics parameters (Mean ± SD) calculated for the first single injection, averaged for all animals (n = 6) after both stages of the study. Three compartment modelling and model‐independent calculation were used
| Parameter | Mean ± SD | |
|---|---|---|
| Group 0.125% | Group 0.05% | |
| Сmax *, µg/L | 35.2 | 15.3 |
| Сmax, µg/L | 31.1 ± 1.2 | 16.0 ± 0.2 |
| AUC0‐144 *, µg.h/L | 1023 | 462 |
| AUC0‐∞, (µg.h)/L | 1682 ± 145 | 1387 ± 83 |
| Cl, L/(h.kg) | 0.022 ± 0.002 | 0.012 ± 0.0007 |
| T½α, h | 0.810 ± 0.016 | 0.797 ± 0.016 |
| T½β1, h | 63.0 ± 1.4 | 64.2 ± 0.5 |
| T½β2, h | 142 ± 30 | 231 ± 49 |
*
– direct model‐independent calculation.