Table 2.
Characteristics and Hepatic Copper Content of Patients With Various Liver Diseases
| Etiology | No. of Patients | Gender (M/F) | Mean Age (Years) | Hepatic Copper Level of Patients (μg/g dry wt) | |||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | 0– | 50– | 100– | 150– | 250+ | ||||
| WD | 178 | 104/74 | 19.7 ± 11.0 | 770.6 ± 393.2 | 0 | 0 | 1 | 9 | 168 |
| Heterozygote | 24 | 20/4 | 19.5 ± 8.0 | 110.7 ± 51.8 | 1 | 12 | 7 | 3 | 1 |
| PBC and PSC | 48 | 13/35 | 44.5 ± 13.1 | 318.2 ± 299.7 | 6 | 7 | 5 | 7 | 23 |
| Viral hepatitis | 198 | 181/17 | 33.4 ± 10.3 | 50.1 ± 35.3 | 126 | 53 | 14 | 5 | 0 |
| AIH | 50 | 22/28 | 38.0.2 ± 15.6 | 82.1 ± 66.0 | 19 | 20 | 6 | 3 | 2 |
| NASH | 40 | 35/5 | 33.5 ± 13.3 | 40.4 ± 28.1 | 31 | 8 | 1 | 0 | 0 |
| GS and DS | 28 | 24/4 | 22.5 ± 8.0 | 37.3 ± 19.7 | 23 | 5 | 0 | 0 | 0 |
| Hemochromatosis | 9 | 9/0 | 31.8 ± 10.1 | 55.4 ± 77.3 | 7 | 1 | 0 | 0 | 1 |
| IPH | 10 | 8/2 | 41.4 ± 14.0 | 59.8 ± 29.0 | 4 | 5 | 1 | 0 | 0 |
| Other diseases | 32 | 26/6 | 33.8 ± 18.0 | 50.2 ± 39.5 | 20 | 9 | 1 | 2 | 0 |
| Origin unknown | 74 | 50/24 | 31.0 ± 18.9 | 165.0 ± 320.6 | 36 | 17 | 6 | 5 | 10 |
| Total | 691 | 492/199 | 29.8 ± 14.2 | 272.8 ± 388.3 | 273 | 137 | 42 | 33 | 206 |
Viral hepatitis, hepatitis B (180), other viral hepatitis (18); GS (26) and DS (2); other diseases, including neurologic diseases other than WD (8), hemolytic jaundice (5), polymyositis (5), venous occlusive disease (4), Budd‐Chiari syndrome (3), alcoholic hepatitis (3), lymphoma (1), glycogen storage disease (1), congenital hepatic fibrosis (1), and schistosomiasis Japonica (1). Origin unknown refers to other diseases origin unknown.
Abbreviations: M, male; F, female; GS, Gilbert syndrome; DS, Dubin‐Johnson syndrome.