Table 4.

Diagnostic performance of placental growth factor (PlGF) and ultrasound parameters to predict small‐for‐gestational age (SGA) < 3^rd and < 10^th centiles in women presenting with reduced symphysis–fundus height (n = 592)

Biomarker/clinical indicator	Sensitivity (% (95% CI)) n/N	Specificity (% (95% CI)) n/N	PPV (% (95% CI)) n/N	NPV (% (95% CI)) n/N
SGA < 3rd centile
EFW < 10th centile	57.9 (46.0–69.1) 44/76	78.8 (75.0–82.3) 402/510	28.9 (21.9–36.8) 44/152	92.6 (89.8–94.9) 402/434
Oligohydramnios*	3.7 (0.5–12.7) 2/54	99.0 (97.0–99.8) 289/292	40.0 (5.3–85.3) 2/5	84.8 (80.5–88.4) 289/341
UA‐PI > 95th centile	16.4 (8.2–28.1) 10/61	96.0 (93.5–97.7) 381/397	38.5 (20.2–59.4) 10/26	88.2 (84.8–91.1) 381/432
PlGF < 5th centile	37.2 (26.5–48.9) 29/78	88.7 (85.7–91.3) 456/514	33.3 (23.6–44.3) 29/87	90.3 (87.4–92.7) 456/505
Abnormal AFI or EFW	57.7 (43.2–71.3) 30/52	79.0 (73.9–83.6) 230/291	33.0 (23.5–43.6) 30/91	91.3 (87.1–94.4) 230/252
Abnormal PlGF or AFI or EFW	69.2 (54.9–81.3) 36/52	72.2 (66.6–77.2) 210/291	30.8 (22.6–40.0) 36/117	92.9 (88.8–95.9) 210/226
SGA < 10th centile
EFW < 10th centile	47.1 (39.7–54.5) 88/187	84.0 (80.0–87.4) 335/399	57.9 (49.6–65.8) 88/152	77.2 (72.9–81.1) 335/434
Oligohydramnios*	3.4 (0.9–8.5) 4/118	99.6 (97.6–100) 227/228	80.0 (28.4–99.5) 4/5	66.6 (61.3–71.6) 227/341
UA‐PI > 95th centile	8.2 (4.3–13.8) 12/147	95.5 (92.6–97.5) 297/311	46.2 (26.6–66.6) 12/26	68.8 (64.1–73.1) 297/432
PlGF < 5th centile	24.5 (18.6–31.2) 47/192	90.0 (86.6–92.8) 360/400	54.0 (43.0–64.8) 47/87	71.3 (67.1–75.2) 360/505
Abnormal AFI or EFW	48.7 (39.3–58.2) 56/115	84.6 (79.3–89.1) 193/228	61.5 (50.8– 71.6) 56/91	76.6 (70.9–81.7) 193/252
Abnormal PlGF or AFI or EFW	57.4 (47.8–66.6) 66/115	77.6 (71.7–82.9) 177/228	56.4 (46.9–65.6) 66/117	78.3 (72.4–83.5) 177/226

Amniotic fluid index (AFI), estimated fetal weight (EFW) and umbilical artery (UA) Doppler were not recorded in all subjects.

^*AFI < 5 cm. NPV, negative predictive value; PI, pulsatility index; PPV, positive predictive value.