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. 2015 Jul 14;68(2):241–253. doi: 10.1111/his.12745

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© 2015 The Authors. Histopathology Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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HER2/neu‐ and hepatocyte growth factor receptor (MET) overexpression in a single patient. A single patient showed overexpression of HER2/neu (A, B) and MET (C, D) in spatially distinct tumour areas. Four serial sections were stained immunohistochemically (A, C) and by chromogenic in‐situ hybridization (B, D). Note the distinct immunoreactions of HER2/neu and MET. HER2/neu showed a characteristic delicate basolateral staining of the cell membrane, while MET immunostaining was also strong within the cytoplasm.