Figure 1.
Effects of (A) intravenous (IV) administration of acylated ghrelin (3 nmol/rat, N = 7–8/group) and (B) intraperitoneal (IP) administration of selective α 2‐AR antagonists (5 m/kg, N = 9/group) on delayed gastric emptying in ICV UCN1‐treated rats. All groups were gavaged with the test meal (1 mL/rat) 1 h after ICV UCN1 (300 pmol/rat) or vehicle. Two hours thereafter, animals were euthanized to determine the percentage of gastric emptying. IV injections were performed immediately after ICV UCN1 or vehicle. IP injections were performed 15 min before ICV UCN1 or vehicle. All values are presented as the mean ± SEM (N = 7–8/group or N = 9–10 group). Significance was identified using the Dunnett's post hoc test following one‐way anova. *p < 0.05, ***p < 0.001.