Table 4.
Lesion histopathology and characterization in various organs of marmosets challenged with Burkholderia pseudomallei strain HBPUB10303a by the inhalational route
| Time (h) | Animal ID | Lung | Spleen | Liver | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| H | Bp | M | T | B | i | H | Bp | M | T | B | i | H | Bp | M | T | B | i | ||
| 12 | 9T | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 139R | 3 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | |
| 119R | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 133P | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 24 | 8T | 1 | 1 | 2 | 1 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 105R | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 2T | 1 | 1 | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 69R | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 36 | 19T | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 1 | 0 |
| 14R | 2 | 4 | 1 | 1 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 128R | 2 | 3 | 3 | 1 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 109R | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 1 | 1 | 0 | 0 | 3 | 1 | |
| 48 | 132R | 2 | 3 | 1 | 1 | 4 | 2 | 2 | 2 | 0 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 3 | 2 |
| 76R | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 1 | 4 | 2 | 2 | 0 | 1 | 1 | 3 | 2 | |
| 154R | 0 | 4 | 1 | 1 | 4 | 2 | 0 | 3 | 0 | 0 | 4 | 2 | 0 | 2 | 0 | 0 | 4 | 2 | |
| 18R | 2 | 3 | 1 | 1 | 4 | 2 | 1 | 2 | 1 | 1 | 4 | 2 | 1 | 1 | 1 | 1 | 4 | 2 | |
| Terminal | 222N | 4 | 4 | 1 | 1 | 4 | 2 | 3 | 4 | 0 | 1 | 4 | 1 | 2 | 3 | 0 | 0 | 3 | 1 |
| 62P | 0 | 2 | 1 | 0 | 2 | 1 | 4 | 4 | 0 | 0 | 4 | 1 | 2.5 | 3 | 0 | 1 | 3 | 1 | |
| 23P | 3 | 4 | 1 | 0 | 4 | 1 | 4 | 4 | 0 | 0 | 4 | 0 | 3 | 3 | 0 | 0 | 3 | 1 | |
| 111R | 1 | 2 | 1 | 0 | 2 | 2 | 4 | 4 | 0 | 1 | 4 | 2 | 2 | 3 | 0 | 0 | 3 | 0 | |
H = average score of lesion severity; Bp = average score of the presence of bacteria in the lesion detected by IHC; M = average score of the presence of macrophages in the lesion detected by IHC; T = average score of the presence of T cells in the lesion detected by IHC; B = average score of the presence of B cells in the lesion detected by IHC; i = average score of the presence of nitric oxide synthase in the lesion detected by IHC; ND, not determined; IHC, immunohistochemistry.