Detection of GIP and GIPR in nestin-positive neuronal progenitors of spinal cord injured-rats. Nestin-positive neuronal progenitors of SCI animals assessed 24 h after surgery co-express GIP (D–F) but not GIPR (A–C). Nestin-positive neuronal progenitors of SCI animals assessed 14 days after surgery co-express GIPR (G–I) and GIP (J, L, and M). White arrows highlight positive-stained cells. GIP, glucose-dependent insulinotropic peptide; GIPR, glucose-dependent insulinotropic peptide receptor; SCI, spinal cord injury. (Original magnification 400×.)