Table 5.
Brain Clusters Demonstrating Altered Functional Connectivity with Seed Regions in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subjects
| Seed—cluster | x | y | z | k | t | Direction of difference |
|---|---|---|---|---|---|---|
| RH cuneus (seed 1)—RH superior temporal gyrus (cluster 1) | 58 | −20 | −4 | 15 | 4.23 | ME/CFS<HC |
| RH parahippocampus (seed 2)—RH Inferior parietal Lobe BA 40 (cluster 1) | 42 | −44 | 40 | 15 | 4.58 | ME/CFS>HC |
| LH lingual gyrus (seed 3)—LH occipital lobe (cluster 1) | −36 | −68 | −2 | 20 | 4.12 | ME/CFS<HC |
| LH lingual gyrus (seed 3)—RH precuneus BA 7 (cluster 2) | 12 | −70 | 34 | 15 | 4.03 | ME/CFS<HC |
| RH cuneus (seed 5)—RH superior midfrontal gyrus (cluster 1) | 34 | 46 | 32 | 16 | 4.01 | ME/CFS<HC |
| RH cuneus (seed 5)—LH middle frontal gyrus BA6 (cluster 2) | −38 | −2 | 52 | 16 | 4.00 | ME/CFS<HC |
Threshold uncorrected p < 0.001; k > 15.
x, y, and z coordinates are in MNI space.
BA, Brodman area; k, cluster size; t, t-value; ME/CFS, myalgic encephalomyelitis/chronic fatigue syndrome.