TABLE 3.
Histological evaluation of lesion severity in 2014 vaccine efficacy study
| Treatment group | No. of granulomas (mean ± SEM)a |
||||
|---|---|---|---|---|---|
| Stage I | Stage II | Stage III | Stage IV | Total (stages I–IV) | |
| Nonvaccinated (n = 10) | 12.2 ± 2.5 | 2.9 ± 1.0 | 4.3 ± 1.2 | 4.0 ± 1.3 | 23.4 ± 4.4 |
| BCG-vaccinated (n = 9) | 1.9 ± 1.2b | 1.3 ± 0.9b | 0.1 ± 0.1b | 0 ± 0b | 3.3 ± 1.9b |
| BCG mutant-vaccinated (n = 10) | 1.1 ± 0.6b | 0.8 ± 0.5b | 0.8 ± 0.7b | 0.1 ± 0.1b | 2.8 ± 1.7b |
a
Microscopic tuberculous lesions were staged (stage I to IV) as described by Wangoo et al. (25). Data are presented as the mean ± SEM of the sum of the number of granulomas representing each stage observed in mediastinal and tracheobronchial lymph nodes and lung histological sections.
b
Value differs from that for nonvaccinated animals (same stage or total) (P < 0.05, ANOVA followed by Tukey's multiple-comparison test).