Seroresponse frequencies to capsid and VPR fusion proteins by vaccination group. The seroresponse frequencies to the capsid (VP1) antigen and to the fusion protein consisting of VPg, viral protease, and the viral RNA-dependent RNA polymerase (VPR) are shown for norovirus vaccine (Vacc) and placebo (Pla) recipients. Time intervals include before and after the first vaccination (days 0 to 21, white bar), before and after the second vaccination (days 21 to 42, stippled bar), and before the first vaccination to after the second vaccination (days 0 to 42, solid bar). The bars represent the 95% confidence intervals around the observed frequencies.