TABLE 2.

IgG antibody rates of change before and after 6 months of age

Assay/antigen tested (P. falciparum isolate)	Time period	Odds ratio (95% CIa) per 1 mo age change	P	P difference between rates of changeb
Serology
LSA1	Before 6 moc	0.72 (0.65–0.80)	<0.001	<0.001
	After 6 mod	1.04 (1.02–1.07)	<0.001
CSP	Before 6 mo	0.64 (0.57–0.72)	<0.001	<0.001
	After 6 mo	1.04 (1.02–1.06)	<0.001
PfCelTOS	Before 6 mo	1.16 (1.04–1.28)	<0.001	0.08
	After 6 mo	1.05 (1.03–1.07)	<0.001
SE50	Before 6 mo	1.20 (1.07–1.34)	0.0025	0.03
	After 6 mo	1.04 (1.02–1.06)	<0.001
SE36	Before 6 mo	0.88 (0.80–0.98)	0.01	0.003
	After 6 mo	1.04 (1.03–1.06)	<0.001
MSP142 (3D7)	Before 6 mo	0.75 (0.68–0.82)	<0.001	<0.001
	After 6 mo	1.04 (1.02–1.06)	<0.001
MSP142 (FVO)	Before 6 mo	0.79 (0.73–0.87)	<0.001	<0.001
	After 6 mo	1.05 (1.03–1.08)	<0.001
MSP142 (FUP)	Before 6 mo	0.66 (0.58–0.74)	<0.001	<0.001
	After 6 mo	1.05 (1.03–1.08)	<0.001
EBA140	Before 6 mo	0.85 (0.77–0.92)	<0.001	<0.001
	After 6 mo	1.06 (1.04–1.09)	<0.001
EBA175	Before 6 mo	0.76 (0.70–0.84)	<0.001	<0.001
	After 6 mo	1.05 (1.03–1.07)	<0.001
EBA181	Before 6 mo	0.75 (0.68–0.82)	<0.001	<0.001
	After 6 mo	1.06 (1.03–1.08)	<0.001
AMA1 (3D7)	Before 12 mo	0.76 (0.71–0.81)	<0.001	<0.001
	After 12 mo	1.03 (1.01–1.06)	0.02
AMA1 (FVO)	Before 12 mo	0.79 (0.75–0.83)	<0.001	<0.001
	After 12 mo	1.04 (1.01–1.07)	0.003
Variant surface antigen assay
BFD 2006	Before 6 mo	0.76 (0.69–0.84)	<0.001	<0.001
	After 6 mo	1.01 (0.99–1.03)	0.33
Msambweni 2006	Before 6 mo	0.60 (0.53–0.68)	<0.001	<0.001
	After 6 mo	1.02 (0.98–1.05)	0.35
3D7	Before 6 mo	0.63 (0.55–0.73)	<0.001	<0.001
	After 6 mo	1.01 (0.97–1.05)	0.63
Growth and invasion inhibition assay
Sial Dep IIA	Before 6 mo	1.18 (1.04–1.34)	0.01	0.02
	After 6 mo	0.98 (0.93–1.04)	0.56
W2mef GIA	Before 6 mo	0.77 (0.68–0.89)	<0.001	<0.001
	After 6 mo	1.05 (1.00–1.10)	0.07
MSP1-19 IIA	Before 12 mo	1.03 (0.94–1.13)	0.53	0.31
	After 12 mo	0.93 (0.81–1.08)	0.35
D10 GIA	Before 12 mo	0.86 (0.78–0.95)	0.004	0.07
	After 12 mo	1.05 (0.92–1.19)	0.491

^aCI, confidence interval.

^bDifference between rates of change between birth to 6 (or 12) months of age and between 6 months of age and 36 months of age (Fisher's exact test).

^cCompared to cord blood responses.

^dCompared to 6-month responses.