Table 1.

Summary of interim analysis results for simulated example.

Dose	$\frac{\sum _{j=1}^{n_1}{y}_{\mathrm{ij}}}{n_1}$	$\frac{\sum _{j=1}^{n_1}{w}_{\mathrm{ij}}}{n_1}$	$\frac{\sum _{j=n_1+1}^{N_1}{w}_{\mathrm{ij}}}{N_1-n_1}$	$\frac{\sum _{j=1}^{N_1}{w}_{\mathrm{ij}}}{N_1}$	${\breve{\theta }}_i$	${\widehat{\theta }}_i$	${\tilde{\theta }}_k$
Control (i = 0)	−1.24	−0.05	0.06	0.02
16 mg/day (i = 1)	0.91	0.56	1.48	1.11	2.15	2.53	2.06
24 mg/day (i = 2)	2.64	2.15	2.43	2.32	3.88	3.96	3.74
32 mg/day (i = 3)	3.62	2.59	0.36	1.25	4.86	3.77	2.30