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Synthesis of S‐palmitoylated and S‐farnesylated peptide methyl esters by Fmoc SPPS. (i) Fmoc‐Cys(Far)‐OH (4 eq.), DIC/HOBt; (ii) SPPS; (iii) ) Fmoc‐Cys(Pal)‐OH (4 eq.), DIC/HOBt; (iv) 1% 1,8‐diazabicyclo [5.4.0]undec‐7‐ene in DMF 2 × 30 s; (v) Fmoc‐AA‐OH (5 eq.), HATU (5 eq.), DIPEA (20 eq.), DCM/DMF (4 : 1); (vi) SPPS; (vii) Cu(OAc)2, pyridine, acetic acid, methanol, DCM, oxygen atmosphere, 3 h.
