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. 2016 Feb 8;6:20503. doi: 10.1038/srep20503

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Copyright © 2016, Macmillan Publishers Limited

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(A) schematic drawing of the epitheliochorial placenta of pig. (B) the maternal-fetal interface of the pig placenta composed of two regions, the interareolar region (composed by trophoblast and luminal epithelium, outside of arrowheads) and the areolar region (located at the mouth of uterine glands, enclosed by arrowheads), respectively. Our findings revealed two paths of cholesterol transport from maternal to fetal circulation, 1 the areolar-gland subunit; 2 the placental epithelial bilayer; (C) Schematic illustration of ABCA1 expression patterns in placental trophoblast in Yorkshire and Meishan pigs, showing that the ABCA1 (in red) was barely expressed in trophoblast which located at the interareolar region (outside of arrowheads) in Yorkshire, but it was highly expressed in the trophoblast in Meishan pigs. (D) Schematic illustration of the proposed mechanism for Meishan pig to increase the placental efficiency in transport cholesterol. Legend: Tr, trophoblast; LE, endometrial luminal epithelium; GE, glandular epithelium; AR, areola of placenta.