FIGURE 1. Adaptive immunity in atherosclerosis.
T and B lymphocytes may positively or negatively influence atherosclerotic plaque through direct action on lesions or through inflammatory cytokine production. Emerging observational data have linked CD8+ and CD4+ T-cell activation to subclinical vascular disease and adverse outcomes among those with HIV infection; relatively less is known about the role of TReg or B lymphocytes in the context of HIV disease. Reproduced with permission from Libby et al.[39]