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. 2016 Feb 8;7:7. doi: 10.3389/fphys.2016.00007

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Copyright © 2016 Wallace, Della Gatta, Ahmad Mir, Kowalski, Kloehn, McConville, Russell and Lamon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of STARS overexpression and inhibition of MRTF-A translocation on known SRF target genes (A,B), STARS mRNA (C) and protein (D), and SRF mRNA (E) and protein (F). mRNA and protein expression levels were respectively measured by real-time qPCR and Western blot. Inhibition of MRTF-A translocation by CCG-1423 treatment decreases the mRNA levels of Egr-1 (A), Junb (B), Stars (C), Srf gene (E) and SRF protein levels (F). It has no effect on STARS protein levels (D). In (A) and (B), post-hoc tests revealed significant differences when comparing the Control DMSO to the STARS DMSO group (^* different from Control DMSO, p < 0.05). DMSO, dimethyl sulfoxide vehicle control; CCG-1423, SRF inhibitor.