Table 2.
The effects of uRCB on body weight, food intake, adipose tissue weight, and serum lipid parameters in HFD-induced obese mice.
| ND | HFD | uRCB 10 mg/kg | uRCB 50 mg/kg | |
|---|---|---|---|---|
| Initial body weight (g) | 20.64 ± 0.08 | 20.92 ± 0.09 | 20.89 ± 0.31 | 20.78 ± 0.23 |
| Final body weight (g) | 26.63 ± 0.49 | 40.05 ± 0.65### | 31.67 ± 0.24∗∗ | 30.05 ± 0.25∗∗∗ |
| Body weight gain (g) | 5.99 ± 0.47 | 19.13 ± 0.71### | 10.78 ± 0.42∗∗ | 8.90 ± 0.43∗∗∗ |
| Food intake (g/day) | 2.75 ± 0.04 | 2.16 ± 0.11 | 2.48 ± 0.00 | 2.68 ± 0.09 |
| FER(1) | 2.22 ± 0.17 | 7.96 ± 0.32### | 4.31 ± 0.17∗∗∗ | 4.27 ± 0.41∗∗∗ |
| Organ weight | ||||
| Epididymal fat (g) | 0.49 ± 0.01 | 2.44 ± 0.04### | 1.67 ± 0.09∗∗ | 1.48 ± 0.04∗∗∗ |
| Perirenal fat (g) | 0.16 ± 0.01 | 1.05 ± 0.03### | 0.67 ± 0.03∗∗ | 0.67 ± 0.01∗∗∗ |
| Liver (g) | 1.29 ± 0.04 | 1.51 ± 0.07 | 1.19 ± 0.02 | 1.14 ± 0.02 |
| Blood parameter | ||||
| GOT (U/L) | 95.20 ± 2.57 | 182.40 ± 14.85# | 103.83 ± 2.33∗ | 90.60 ± 1.61∗ |
| GPT (U/L) | 29.2 ± 3.31 | 42.80 ± 2.47 | 38.17 ± 1.76 | 29.80 ± 0.75 |
| Creatinine (mg/dL) | 0.32 ± 0.02 | 0.16 ± 0.01 | 0.15 ± 0.01 | 0.10 ± 0.00 |
| BUN (mg/dL) | 27.10 ± 1.04 | 27.88 ± 0.87 | 26.65 ± 0.57 | 27.28 ± 0.37 |
| Glucose (mg/dL) | 187.20 ± 5.48 | 300.50 ± 12.52# | 224.67 ± 4.32 | 182.25 ± 5.32∗ |
| TC (mg/dL) | 124.20 ± 1.73 | 195.20 ± 3.11### | 181.67 ± 3.37∗ | 171.50 ± 2.27∗ |
| TG (mg/dL) | 173.00 ± 6.14 | 247.20 ± 10.84# | 188.67 ± 5.02∗ | 186.80 ± 5.98∗∗ |
| HDL-C (mg/dL) | 76.67 ± 1.19 | 57.00 ± 1.10# | 61.67 ± 2.96 | 75.67 ± 2.03∗ |
| LDL-C(2) (mg/dL) | 22.13 ± 2.42 | 83.33 ± 2.68### | 80.40 ± 3.90 | 72.13 ± 3.39∗ |
(1)FER (food efficiency ratio) = body weight gain/food intake
(2)LDL-C (LDL-cholesterol) = total cholesterol − HDL-cholesterol − triglyceride/5
Values are expressed as mean ± SE (n = 5). # P < 0.05 and ### P < 0.001 compared with the ND group; ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001 compared with the HFD group.