Table 1.
Summary of current phenotypes described for different DC subsets.
| DC type | Phenotype/markers | Function | Reference |
|---|---|---|---|
| Plasmacytoid DC (pDC) | MHC-II, CD45RA/B220, Ly6C/GR-1, Siglec-H |
Type I-IFN synthesis | [11–13] |
| Conventional DC type 1 (cDC1) | CD8α, CD103 (mice); CD141/BDCA3 (humans) |
Antigen cross-presentation, CD8α + T cell activation | [15, 16, 18, 19] |
| Conventional DC type 2 (cDC2) | CD11b, CD172/SIRPα (mice); CD1c/BDCA1 (humans) |
CD4+ T cell polarization | [17, 20, 21] |
| Monocyte-derived DC (MoDC) | CD11c, MHC-II, F4/80, CD64 (mice); CD1a (humans) | Antigen presentation at inflammatory sites | [23, 24] |
| Langerhans cell (LC) | MHC-II, Langerin | Antigen presentation in the skin | [25–27] |