Table 3.
Scoring of morphological changes observed in control and experimental groups by light microscope (n = 6).
| Findings | Control group | DLD group | DHD group | DOX treated group | DOX/DLD group | DOX/DHD group |
|---|---|---|---|---|---|---|
| (i) Glomerular vacuolations | − | − | − | ++++ | + | + |
| (ii) Enlarged renal corpuscles | − | − | − | ++++ | + | − |
| (iii) Tubular cells vacuolations | − | + | − | ++++ | + | + |
| (iv) Lumen widening | − | − | − | ++++ | + | − |
| (v) Distortion and Degeneration | − | − | − | ++++ | + | − |
| (vi) Casts | − | − | − | − | − | − |
Animal groups tested are control untreated group, animals treated with diacerein (25 mg/kg/day, DLD) and diacerein (50 mg/kg/day, DHD), respectively, and animals treated with doxorubicin (DOX, 15 mg/kg), or with DOX together with low or high dose of diacerein (DOX/DLD or DOX/DHD), respectively.
Normal (−), in-between normal and mild (+), mild (++), moderate (+++), and severe (++++) [9].