Fig. 1.

Comparison of the novel CYP2D6 alleles identified in this cohort to similar alleles. M33388 and AY545216 reference sequences were used for numbering and as CYP2D6*1 respectively. Black boxes represent sequence variation at a specific locus. A star in a black box represents a novel SNP resulting in non-synonymous amino acid changes and thus allele defining (or sub-variant defining) SNPs, and an x represents regions not sequenced. M33388, AY545216 and CYP2D6*2A are depicted as presented on the Nomenclature Committee website (www.cypalleles.ki.se) or as represented by Gaedigk et al. (2007).