Figure 4. CLEC-2 expression on DC induces T regulatory cells.

DCs were transfected with CLEC-2 and subsequently cultured with T cells for 5 days. A. Histograms depict the expression of CLEC-2 on DCs 48h after transfection. Mock is mock transfected DC. Data is representative of 5 such experiments. Bar diagram depicts the levels of B. IFN-γ and C. IL-10 and secreted by T cells. Data is mean +/− S.E. of 6 different subjects. C. Bar graph depicts depicts the percentage of FoxP3⁺ cells in gated CD4⁺CD25⁺CD127^lo cells in DC-T cell coculture. Data is mean +/− S.E. of 6 subjects.