Table 3. Comparison between Objective Response, Early Tumor Shrinkage and Deepness of response characteristics.

	OR Objective Response	ETS Early Tumor Shrinkage	DoR Deepness of response
Significance	The proportion of patients with tumor size reduction of a predefined amount and for a minimum period of time	The proportion of patients who experienced a predefined relative decrease of tumor size at the very first radiological assessment	The percentage of tumor shrinkage, in terms of longest diameter (LD) or calculated tumor volume, observed at the nadir compared to baseline
Time of assessment	Anytime	At a prespecified early point time(6–8 weeks since treatment start)	Anytime
Confirmation	Needed	Not Needed	Not Needed
Variable evaluation	Binary or in 4 classes	Continuous or in binary	Continuous or in 5 classes