Table 1. log2(fold change) and rank of snoRNA genes among the top-10 upregulated SNORs in tumours after at least one of the treatments, RA and THAL as sole agents, or in the combination RA + THAL.
| log2(fold change) | Rank | |||||
|---|---|---|---|---|---|---|
| Gene | RA-Ctrl | (RA + THAL)-Ctrl | THAL-Ctrl | RA | RA + THAL | THAL |
| SNORA23 | 1.45 | 1.04 | 0.61 | 3 | 1 | 4 |
| SNORA68 | 1.43 | 0.94 | 0.95 | 4 | 2 | 1 |
| SNORA60 | 0.94 | 0.84 | 0.12 | 16 | 3 | 41 |
| SNORD74 | 1.01 | 0.83 | 0.22 | 10 | 4 | 19 |
| SNORD116–24 | 1.38 | 0.81 | 0.49 | 5 | 5 | 7 |
| SNORA42 | 1.48 | 0.74 | 0.44 | 2 | 6 | 8 |
| SNORA71A | 1.24 | 0.69 | 0.62 | 6 | 7 | 3 |
| SNORA3 | 1.13 | 0.67 | 0.10 | 8 | 8 | 43 |
| SNORA73A | 0.90 | 0.67 | 0.60 | 18 | 9 | 5 |
| SNORA20 | 1.49 | 0.67 | 0.40 | 1 | 10 | 9 |
| SNORA7B | 1.08 | 0.59 | 0.23 | 9 | 11 | 18 |
| SNORA24 | 0.74 | 0.49 | 0.40 | 26 | 15 | 10 |
| SNORA71C | 0.98 | 0.31 | 0.68 | 15 | 32 | 2 |
| SNORD114–3 | 1.14 | -0.01 | 0.51 | 7 | 206 | 6 |
A considerable degree of overlap was observed: 6 of 14 genes were in the top-10 after all three treatments.