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. 2015 Aug 21;6(30):28999–29015. doi: 10.18632/oncotarget.4905

Figure 7. ADAR1 transcriptionally regulates miR-222 processing at the pri-miR level.

Figure 7

A–C. Expression levels of pri-miR-222 in ADAR1-KD and scramble cells (A); ADAR1-p110 and Mock cells (B); and ΔCAT-S and Mock cells (C) were assessed by qRT-PCR and normalized to HPRT expression. Experiments were performed three times in triplicates. D. miR-222 putative promoter was cloned into pGL4.14 vector and luciferase assays were performed with ADAR1-p110 or Mock constructs. Relative luciferase activity was calculated relative to control (i.e., Mock in the presence of pGL4.14 empty vector). Experiment was performed in sixplicates. Representative experiment out of three.