Skip to main content
. 2015 Aug 24;6(30):29016–29033. doi: 10.18632/oncotarget.5032

Figure 4. Ectopic over-expression of SERPINE1 increases migration, reduces proliferation and inhibits apoptotic induction in the UM-SCC-74B HNSCC cell line.

Figure 4

A. SERPINE1 mRNA levels in six HNSCC cell lines. B. SERPINE1 over-expression in the stably transduced UM-SCC-74B cell line (74B-SerpE1up), as analyzed by Western-Blot (left) and RT-PCR (right). Transwell migration C. and cell proliferation D. assays in UM-SCC-74B and 74B-PAI1up cells. E. Representative images of DAPI stained nuclei in UM-SCC-74B and 74B-SerpE1up cells before and after 16 hours of 15 μM cisplatin treatment (left) Over-expression of SERPINE1 reduces the number of apoptotic figures in cisplatin-treated cells (right). **p < 0.01 and ***p < 0.001.