Table 1. Characteristics of patients included in the retrospective study.

Variable	All patients (n = 80)	High SERPINE1 (+++) (n = 29)	Intermediate or Low SERPINE1 (−/+/++) (n = 51)	P value1
Sex
Men	76	26	50	0.182
Women	4	3	1
Age (years)
<60	30	11	19	0.952
>60	50	18	32
Tumor site
Oral cavity	7	5	2	0.095
Oropharynx	13	2	11
Hypopharynx	13	4	9
Larynx	47	18	29
Tumor size (T)
T2	8	4	4	0.690
T3	51	18	33
T4	21	7	14
Node (N)
Positive	44	19	25	0.157
Negative	36	10	26
Tumor differentiation
Well	6	2	4	0.438
Moderate	67	26	41
Poor	7	1	6
Tobacco
Non-smoker	4	2	2	0.560
<20 cigarette/day	5	1	4
>20 cigarette/day	70	26	44
Cigar or pipe	1	—	1
Alcohol
Non-drinker	13	7	6	0.152
<100 gr./day	32	10	22
>100 gr./day	35	12	23
Local recurrence
Yes	15	8	7	0.111
No	65	21	44
Metastatic recurrence
Yes	9	6	3	0.045
No	71	23	48
Treatment
Radiotherapy	42	16	26	0.720
Surgery+/−RT	38	13	25

¹Mann Whitney/Kruskal Wallis