Table 2. Characteristics of patients included in the prospective study.

Variable	All patients (n = 190)	High SERPINE1 (n = 114)	Low SERPINE1 (n = 76)	P value1
Sex
Men	172	105	67	0.363
Women	18	9	9
Age (years)
<60	86	53	33	0.677
>60	104	61	43
Tumor site
Oral cavity	31	17	14	0.391
Oropharynx	65	43	22
Hypopharynx	22	15	7
Larynx	62	39	33
Tumor size (T)
T1	12	4	8	0.145
T2	60	34	26
T3	73	45	28
T4	45	31	14
Node (n)
Positive	111	73	38	0.054
Negative	79	41	38
Tumor differentiation
Well	13	5	8	0.085
Moderate	163	99	64
Poor	14	10	4
Tobacco
Non-smoker	14	7	7	0.687
<20 cigarette/day	28	15	13
>20 cigarette/day	146	91	55
Cigar or pipe	2	1	1
Alcohol
Non-drinker	34	16	18	0.037
<100 gr./day	81	45	36
>100 gr./day	75	53	22
Local recurrence
Yes	49	36	13	0.028
No	141	78	63
Metastatic recurrence
Yes	65	46	19	0.029
No	125	68	57
Treatment
Radiotherapy	51	27	24	0.124
CDDP-based CRT	74	52	22
Cetux-based CRT	6	4	2
Surgery+/−RT	59	31	28

¹Mann Whitney/Kruskal Wallis