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. 2015 Aug 21;6(30):29268–29284. doi: 10.18632/oncotarget.4922

Figure 4. Diabetic conditions promoted oral carcinogenesis in vivo.

Figure 4

A. Experimental scheme to establish DM mice with 4NQO induced oral cancer. All animals were sacrificed after 20 weeks of initial 4-NQO feeding. The number of animals for each experimental group was shown in parenthesis. Histological analysis for B. Hematoxylin & Eosin, C. Ki67 and E. mTORC1 downstream regulator phosphorylated S6 protein showed that the more aggressive oncogenic lesions were detected in DM mice compared with time-matched non-DM animals; D. Quantification of precancerous/tumor incidence in mice treated with STZ and 4-NQO.