Table 1. Significant differences in levels of cytokines in wound fluid in relation to post-surgery days.

Cytokine	Group	N	M pg/ml	X25% pg/ml	X75% pg/ml	P value
IL-1β	Day 1	6	1541.37	370.31	2746.69	0.050
	Day 2	10	397.12	29.28	584.31
	Day 3	12	149.44	31.03	939.91
	Day 4	10	177.79	42.96	425.00
IL-4	Day 1	6	27.09	20.24	38.16	0.006
	Day 2	10	16.55	12.83	19.71
	Day 3	12	13.96	11.07	23.54
	Day 4	10	11.38	8.12	17.52
IL-6	Day 1	6	226176.00	170909.33	362337.25	0.003
	Day 2	10	118763.50	75960.74	216038.77
	Day 3	12	78556.41	43517.65	160951.69
	Day 4	10	46990.56	23458.15	96296.32
IL-17F	Day 1	6	101.37	86.48	125.01	0.009
	Day 2	10	71.21	45.92	86.97
	Day 3	12	50.28	33.91	75.20
	Day 4	7	38.99	32.22	73.26
IL-21	Day 1	6	1136.15	912.43	1521.65	0.003
	Day 2	10	604.90	349.05	855.75
	Day 3	11	482.67	378.77	973.30
	Day 4	9	340.79	204.17	576.16
IL-23	Day 1	6	82.90	73.97	159.51	0.046
	Day 2	9	43.63	17.61	73.48
	Day 3	7	40.00	10.77	70.48
	Day 4	5	20.17	10.77	63.72
IL-25	Day 1	6	16.15	13.17	26.48	0.004
	Day 2	10	11.59	5.06	14.00
	Day 3	11	6.11	5.27	11.59
	Day 4	9	4.41	1.62	7.11
IL-31	Day 1	6	54.91	45.50	83.43	0.001
	Day 2	10	43.34	22.60	51.08
	Day 3	12	27.54	22.60	38.99
	Day 4	10	23.50	15.28	27.94
IL-33	Day 1	6	213.63	44.66	296.57	0.003
	Day 2	10	55.65	33.48	113.35
	Day 3	12	39.87	29.12	53.27
	Day 4	10	23.80	17.77	30.94
IFNγ	Day 1	6	210.72	184.53	288.92	0.011
	Day 2	8	145.83	85.98	197.05
	Day 3	8	116.49	75.84	159.61
	Day 4	7	98.64	44.67	128.45
CD40L	Day 1	6	898.05	314.94	1322.21	<0.0001
	Day 2	10	301.67	141.66	339.24
	Day 3	12	158.76	139.83	250.48
	Day 4	10	130.35	94.26	174.03

Levels are expressed as median and range in X_25%, X_75%.

Differences were considered to be significant at the P < 0.05 level. Some data was missing because the concentration was undetectable.

IL = Interleukin; IFNγ = Interferon γ; CD40L = CD40 ligand.