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. 2015 Jul 22;6(30):29440–29455. doi: 10.18632/oncotarget.4984

Figure 3. KIR/KIR-L blockade enhances NK cell cytotoxicity against pre-B ALL.

Figure 3

A. Pre-B ALL cell lines express various levels of HLA class I molecules as assessed by flow cytometry. Representative histograms are shown. B. HLA class I genotype is shown for REH, KOPN8 and Nalm6 cells. C. Cytotoxic assays against Nalm6 (5:1 E:T ratio) were performed with KIR/HLA class I matched NK cells (Bw6 C1/C2 donors) in the presence or absence of HLA blocking antibodies. Means of 3 independent experiments performed in triplicates are shown. Means of specific lysis are represented with SEM. Paired t-test was used for statistical comparison *p ≤ 0.05.