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. 2015 Jul 22;6(30):29440–29455. doi: 10.18632/oncotarget.4984

Figure 6. TRAIL mediated apoptosis plays a major role in pre-B ALL lysis by activated NK cells.

Figure 6

A. All 3 pre-B ALL cell lines express the death receptors, TRAIL-R1 and TRAIL-R2, as assessed by flow cytometry. Representative histograms are shown for each pre-B ALL cell line (black line: isotype control; gray filled specific antibody). B. NK cell-mediated cytotoxic activity against all 3 pre-B ALL is significantly inhibited by the blockade of TRAIL/TRAIL-R interactions, using a specific blocking antibody against TRAIL (5:1 E:T ratio). Paired t-test was used for statistical comparison, **p ≤ 0.01, *p ≤ 0.05.